Persson B E, Ronquist G, Ekblom M
Department of Urology, University Hospital, Uppsala, Sweden.
J Urol. 1996 Mar;155(3):961-4.
Nonbacterial prostatitis is a common problem in young men. It is a disease that is often recurrent and each episode lasts for several months. Different causative mechanisms of the disease have been discussed, including identified and unidentified microorganisms, stone formation and psychological factors. We have demonstrated in a previous study that urinary reflux (as shown by a high creatinine concentration in prostatic fluid) occurs to a varying extent into the prostatic ducts, and this reflux has been related to prostatic pain and urate concentration in expressed prostatic secretion.
We performed a paralled double-blind controlled study of the objective and subjective effects of allopurinol on patients with nonbacterial prostatitis. Twenty patients received placebo, 18 received 300 mg. allopurinol daily and 16 received 600 mg allopurinol daily for 240 days. All patients began medication at the same time regardless of whether the disease was in an active state. No side effects were noted in the treatment groups.
Significant effects were noted on the concentrations of serum urate, urine urate, expressed prostatic secretion urate, expressed prostatic secretion xanthine and subjective discomfort.
Allopurinol has a significant, positive effect on nonbacterial prostatitis. It is safe and worthy of trial for all at least a 3-month period at each episode to relieve the symptoms of nonbacterial prostatitis.
非细菌性前列腺炎是年轻男性的常见问题。这是一种常复发的疾病，每次发作持续数月。该病不同的致病机制已被探讨，包括已识别和未识别的微生物、结石形成及心理因素。我们在之前的一项研究中表明，尿液反流（如前列腺液中肌酐浓度升高所示）在不同程度上会发生至前列腺导管，且这种反流与前列腺疼痛及前列腺液中尿酸盐浓度有关。
我们对别嘌醇治疗非细菌性前列腺炎患者的客观和主观效果进行了一项平行双盲对照研究。20名患者接受安慰剂，18名患者每日服用300毫克别嘌醇，16名患者每日服用600毫克别嘌醇，为期240天。所有患者无论疾病是否处于活动期均同时开始用药。治疗组未观察到副作用。
在血清尿酸盐、尿尿酸盐、前列腺液尿酸盐、前列腺液黄嘌呤浓度及主观不适方面均观察到显著效果。
别嘌醇对非细菌性前列腺炎有显著的积极作用。它安全，每次发作至少试用3个月以缓解非细菌性前列腺炎症状是值得的。
