Bhatnagar A
Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, USA.
J Cardiovasc Pharmacol. 1995 Sep;26(3):343-7. doi: 10.1097/00005344-199509000-00001.
We studied the effects of n-propyl gallate (n-PG) on Langendorff preparations of isolated rat hearts. Perfusion of the hearts with Krebs-Henseleit (KH) solution containing 20 microM n-PG did not cause a statistically significant change in either left ventricular systolic pressure (LVSP), end-diastolic pressure (LVEDP), developed pressure (LVDP), or heart rate (HR), indicating that n-PG has little acute myocardial toxicity. The effects of n-PG on the reperfused and ischemic myocardium were tested in hearts subjected to 15-min global P4 the ischemic hearts with KH buffer resulted in the recovery of the LVDP to 66 +/- 7% (mean +/- SEM, n = 11) and the recovery of the rate-pressure product (RPP) to 65 +/- 7% of their preischemic values. The LVEDP of the reperfused hearts was 30 +/- 5 mm Hg as compared with the preischemic LVEDP of 5.2 +/- 0.9 mm Hg. The difference between the coronary flow rate of the preischemic hearts (15.4 +/- 0.8 ml/min) and the reperfused hearts (13.9 +/- 0.9 ml/min) was not statistically significant (p > 0.05). Addition of n-PG, at the time of reperfusion, resulted in with KH buffer containing 20 microM n-PG had LVEDP of 6.2 +/- 0.4 mm Hg, and both LVDP and RPP recovered to 92 +/- 4% of the preischemic control.(ABSTRACT TRUNCATED AT 250 WORDS)
我们研究了没食子酸正丙酯（n-PG）对离体大鼠心脏Langendorff标本的影响。用含20微摩尔n-PG的Krebs-Henseleit（KH）溶液灌注心脏，左心室收缩压（LVSP）、舒张末期压力（LVEDP）、发展压力（LVDP）或心率（HR）均未出现统计学上的显著变化，这表明n-PG几乎没有急性心肌毒性。在经历15分钟全心缺血的心脏中测试n-PG对再灌注和缺血心肌的影响。用KH缓冲液灌注缺血心脏后，LVDP恢复到缺血前值的66±7%（平均值±标准误，n = 11），心率-压力乘积（RPP）恢复到缺血前值的65±7%。再灌注心脏的LVEDP为30±5毫米汞柱，而缺血前LVEDP为5.2±0.9毫米汞柱。缺血前心脏的冠状动脉血流量（15.4±0.8毫升/分钟）与再灌注心脏的冠状动脉血流量（13.9±0.9毫升/分钟）之间的差异无统计学意义（p>0.05）。在再灌注时添加n-PG，用含20微摩尔n-PG的KH缓冲液灌注后，LVEDP为6.2±0.4毫米汞柱，LVDP和RPP均恢复到缺血前对照值的92±4%。（摘要截断于250字）
