一种睾丸源性非甾体化合物的神经内分泌效应。
Neuroendocrine effects of a non-steroidal compound of testicular origin.
作者信息
Iturriza F, Carlini M R, Piva F, Martini L
出版信息
Experientia. 1977 Mar 15;33(3):396-8. doi: 10.1007/BF02002849.
PMID:858378
Abstract
The effects of the compound (+)-1,4-diphenylbutane-2,3-diol (DPB, synthetized in the testes) on gonadotropin secretion have been studied in castrated male rats. DPB, when injected subcutaneously, does not modify serum levels of LH and FSH. On the contrary, the local implantation of DPB in the median eminence of the hypothalamus results in a significant elevation of serum FSH. It is suggested that DPB may play a physiological role in the control of FSH release.
摘要
已在去势雄性大鼠中研究了化合物（+）-1,4-二苯基丁烷-2,3-二醇（DPB，在睾丸中合成）对促性腺激素分泌的影响。皮下注射DPB时，不会改变血清中促黄体生成素（LH）和促卵泡生成素（FSH）的水平。相反，将DPB局部植入下丘脑正中隆起会导致血清FSH显著升高。提示DPB可能在FSH释放的调控中发挥生理作用。
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