Minardi G, Bottini E, Gallazzi A
Farmaco Sci. 1977 Feb;32(2):147-55.
During the study of the transpositions undergone by the amide of canphen-4-carboxylic acid on treatment with concentrated hydrochloric acid, the formation of the amide of 2-chlorobornan-4-carboxylic acid alone, arising in two polymorphous forms, has been confirmed. Its reduction produced 2-chloro-4-aminomethylbornane; the detachment of hydrochloric acid at the amide of canphen-1-carboxylic acid.
在研究莰-4-羧酸酰胺用浓盐酸处理时发生的转位反应过程中,已证实仅生成2-氯莰烷-4-羧酸酰胺,且有两种多晶型形式。其还原反应生成2-氯-4-氨甲基莰烷;莰-1-羧酸酰胺处盐酸的脱离。