Torii M, Kubo K, Sasaki T
Bioregulation and Physical Fitness Laboratory, Faculty of Engineering, Kyushu Institute of Technology, Fukuoka, Japan.
Neurosci Lett. 1995 Aug 11;195(3):167-70. doi: 10.1016/0304-3940(95)11809-b.
The effects of intra-third-ventricular (ITV) injection of naloxone (NLX), an opioid receptor antagonist, on lordosis behavior were studied in ovariectomized female rats given a horizontal half-circle cut located just above the anterior commissure (ARD) and subcutaneously (s.c.) treated with estradiol benzoate (EB) and progesterone (Prog). In ARD-sham control animals, lordosis quotient (LQ) was 78.8 +/- 4.2% (SE,n = 8). LQ (48.3 +/- 7.2%, SE, n = 8) in the ARD-sham rats significantly decreased with the ITV injection of NLX at the time of s.c. EB-priming. In contrast, lordosis reflex in the ARD-operated animals was maximally facilitated (sham versus ARD, P < 0.01). LQ in the ARD-operated rats did not decrease with the ITV injection of NLX at the s.c. EB-priming. The present results suggest that the opioidergic systems modulate an initial phase of estrogen action to induce lordosis and play a part in neural input from the forebrain structures to regulate female sexual receptivity.
在接受了位于前连合上方的水平半圆切口（ARD）且皮下注射苯甲酸雌二醇（EB）和孕酮（Prog）的去卵巢雌性大鼠中，研究了向第三脑室内（ITV）注射阿片受体拮抗剂纳洛酮（NLX）对脊柱前凸行为的影响。在ARD假手术对照动物中，脊柱前凸商（LQ）为78.8±4.2%（标准误，n = 8）。在皮下注射EB启动时，ARD假手术大鼠的LQ（48.3±7.2%，标准误，n = 8）随着ITV注射NLX而显著降低。相比之下，ARD手术动物的脊柱前凸反射得到最大程度的促进（假手术组与ARD组相比，P < 0.01）。在皮下注射EB启动时，ARD手术大鼠的LQ并未随着ITV注射NLX而降低。目前的结果表明，阿片能系统调节雌激素作用的初始阶段以诱导脊柱前凸，并在前脑结构的神经输入中发挥作用以调节雌性的性接受能力。
