Samochowiec J, Kleinrok Z, Horodnicki J
Department of Psychiatry, Pomeranian Medical Academy, Szczecin, Poland.
Pharmazie. 1995 Dec;50(12):815-8.
This study was undertaken to evaluate the influence of acute doses of ethanol, chronic ethanol administration and the withdrawal syndrome on central dopaminergic neurotransmission in 700 rats. The ethanol effects were differentiated by their influence on D1 and D2 receptors using following dopaminergic ligands. SKF 38393 (2.5 mg/kg), SCH 23,390 (0.5 mg/kg), pimozide (1 mg/kg), PPHT (2 mg/kg). It was found that ethanol in a low single dose (1.0 g/kg p.o.) increased DA level in rats' brain. In chronic alcoholized rats SKF 38,393 increased the D1 receptor answer in biochemical and behavioural experiments. During the withdrawal period in rats D2 agonist PPHT reversed abstinence symptoms whereas other DA antagonists normalized only some parameters altered by ethanol removal from the diet.
本研究旨在评估急性剂量乙醇、慢性乙醇给药及戒断综合征对700只大鼠中枢多巴胺能神经传递的影响。使用以下多巴胺能配体，根据乙醇对D1和D2受体的影响来区分其作用。SKF 38393（2.5毫克/千克）、SCH 23390（0.5毫克/千克）、匹莫齐特（1毫克/千克）、PPHT（2毫克/千克）。结果发现，低单次剂量（口服1.0克/千克）乙醇可提高大鼠脑内多巴胺水平。在慢性酒精中毒大鼠中，SKF 38393在生化和行为实验中增强了D1受体反应。在大鼠戒断期，D2激动剂PPHT可逆转戒断症状，而其他多巴胺拮抗剂仅使因从饮食中去除乙醇而改变的一些参数恢复正常。
