Samochowiec J, Kleinrok Z, Jagiełło-Wójtowicz E, Horodnicki J, Rommelspacher H, Schmidt L G
Department of Clinical Neurobiology, Free University of Berlin, Germany.
Pol J Pharmacol. 1997 Aug;49(4):221-7.
A single dose of ethanol (1 g/kg p.o.) significantly decreased, whereas higher doses of ethanol (2 or 3 g/kg p.o.) significantly increased the serum prolactin (PRL) concentration. Administration of ethanol at a dose of 2 g/kg p.o. for 4 weeks did not affect this parameter but the ethanol withdrawal syndrome caused a significant rise in the serum PRL level. Chronic studies showed that D1-dopaminergic agonist SKF 38390 (2.5 mg/kg) significantly raised serum PRL levels in rats. This effect was reversed by long-lasting treatment of rats with ethanol and ethanol withdrawal. Pimozide (1 mg/kg), D2 antagonist, increased PRL in those rats. On the other hand, D1-antagonist SCH 23390 (0.5 mg/kg) and D2-agonist PPHT (0.5 mg/kg) were without effect in rats administered ethanol for a long period of time. In rats with ethanol withdrawal syndrome, administration of D1-antagonist SCH 23390 (0.5 mg/kg) also did not affect the serum PRL concentrations. However, D1-agonist SKF 38393 (2.5 mg/kg) and D2-antagonist pimozide (1 mg/kg) increased the serum PRL level in rats with ethanol withdrawal syndrome, whereas D2 agonist PPHT (2 mg/kg) decreased PRL level in serum. Thus, the acute effect of ethanol on PRL level appears to be dose-dependent. It seems that chronic ethanol administration and its withdrawal especially affected D1 receptor.
单次口服乙醇（1克/千克）可显著降低血清催乳素（PRL）浓度，而较高剂量的乙醇（2或3克/千克，口服）则可显著升高该浓度。以2克/千克的剂量口服乙醇4周对该参数无影响，但乙醇戒断综合征会导致血清PRL水平显著升高。慢性研究表明，D1多巴胺能激动剂SKF 38390（2.5毫克/千克）可显著提高大鼠血清PRL水平。乙醇长期处理及乙醇戒断可逆转这一效应。D2拮抗剂匹莫齐特（1毫克/千克）可使这些大鼠的PRL升高。另一方面，D1拮抗剂SCH 23390（0.5毫克/千克）和D2激动剂PPHT（0.5毫克/千克）对长期给予乙醇的大鼠无作用。在患有乙醇戒断综合征的大鼠中，给予D1拮抗剂SCH 23390（0.5毫克/千克）也不影响血清PRL浓度。然而，D1激动剂SKF 38393（2.5毫克/千克）和D2拮抗剂匹莫齐特（1毫克/千克）可使患有乙醇戒断综合征的大鼠血清PRL水平升高，而D2激动剂PPHT（2毫克/千克）则可降低血清PRL水平。因此，乙醇对PRL水平的急性作用似乎呈剂量依赖性。慢性乙醇给药及其戒断似乎尤其影响D1受体。
