Zuo D, Yu P H
Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada.
Prog Brain Res. 1995;106:199-205.
We have observed that the survival of dopamine neuroblastoma (SH-SY5Y) cells in co-cultures with C-6 glioma in serum-deprived media is slightly but significantly enhanced by R-(-)-deprenyl, a selective monoamine oxidase B inhibitor. This drug, however, does not directly affect the viability of SH-SY5Y cells or glioma cells in serum or serum-deprived media. The results suggest that R-(-)-deprenyl enhances astroglial trophic support in favor of neuronal survival.
我们观察到，在血清缺乏的培养基中，多巴胺神经母细胞瘤（SH-SY5Y）细胞与C-6胶质瘤共培养时，选择性单胺氧化酶B抑制剂R-(-)-司来吉兰可使其存活率略有但显著提高。然而，该药物在血清或血清缺乏的培养基中并不直接影响SH-SY5Y细胞或胶质瘤细胞的活力。结果表明，R-(-)-司来吉兰增强了星形胶质细胞的营养支持作用，有利于神经元存活。
