Li H W, Wang X, Han Q D
Institute of Vascular Medicine, Third Hospital, Beijing Medical University, Beijing.
Sheng Li Ke Xue Jin Zhan. 1995 Jul;26(3):209-12.
The release of intracellular stored Ca2+ is mainly regulated by an inositol 1,4,5-triphosphate (IP3) receptor system and a ryanodine receptor system. The former induces Ca2+ release directly when the receptors are bound to IP3. The later may function through the Ca2+ induced Ca2+ release mechanism when the ryanodine receptors are activated. Cyclic ADP ribose, a metabolite of NAD+ which is regulated by complicated mechanisms, is one of the most important factors causing activation of ryanodine receptors. The two systems may interact with each other to regulate Ca2+ release from intracellular calcium pool.
细胞内储存的Ca2+的释放主要受肌醇1,4,5-三磷酸（IP3）受体系统和兰尼碱受体系统调控。前者在受体与IP3结合时直接诱导Ca2+释放。后者在兰尼碱受体被激活时可能通过Ca2+诱导的Ca2+释放机制发挥作用。环ADP核糖是NAD+的一种代谢产物，其受复杂机制调控，是导致兰尼碱受体激活的最重要因素之一。这两个系统可能相互作用以调节细胞内钙库的Ca2+释放。
