Dahl O E, Aspelin T, Arnesen H, Seljeflot I, Kierulf P, Ruyter R, Lyberg T
Dept. of Medicine, Ullevaal University Hospital, Oslo, Norway.
Thromb Res. 1995 Nov 15;80(4):299-306. doi: 10.1016/0049-3848(95)00180-y.
Hip replacement surgery (HRS) is associated with a high frequency of deep vein thrombosis (DVT). At the same time there is a substantial systemic and local activation of coagulation. This study indicates that discontinuation of thromboprophylaxis one week after surgery may allow a second wave of coagulation and fibrinolysis activation to occur. An almost parallel increase in plasma TAT and D-dimer levels between the 6th and the 35th postoperative day may indicate late DVT formation. Repeated bilateral ascending venography is though to be necessary to evaluate the suitability of using selected activation markers of the coagulation and fibrinolytic systems as indices of DVT formation.
髋关节置换手术（HRS）与深静脉血栓形成（DVT）的高发生率相关。与此同时，存在大量的全身和局部凝血激活。本研究表明，术后一周停止血栓预防可能会引发第二轮凝血和纤溶激活。术后第6天至第35天血浆凝血酶-抗凝血酶复合物（TAT）和D-二聚体水平几乎平行升高，这可能表明存在晚期DVT形成。不过，可能需要重复进行双侧上行静脉造影，以评估使用凝血和纤溶系统的选定激活标志物作为DVT形成指标的适用性。
