大鼠血液和血浆中血清素测量值的变化——尼古丁和/或不同应激暴露的影响

Changes in blood and plasma serotonergic measurements in rats--effect of nicotine and/or exposure to different stresses.

作者信息

Takada Y, Ihara H, Urano T, Takada A

机构信息

Department of Physiology, Hamamatsu University School of Medicine, Shizuoka-ken, Japan.

出版信息

Thromb Res. 1995 Nov 15;80(4):307-16. doi: 10.1016/0049-3848(95)00181-p.

DOI:10.1016/0049-3848(95)00181-p

PMID:8585043

Abstract

Effects of two kinds of stress on plasma and whole blood serotonergic measurements were studied in nicotine administered rats. Plasma tryptophan levels increased after footshock stress. Stress given to nicotine administered rats resulted in decrease in plasma tryptophan levels. Although there was no change in 5-HT levels in whole blood, footshock increased plasma levels of 5-HT, and restraint stress decreased its levels. Plasma and whole blood 5-HIAA levels increased in rats given stress and nicotine. 5-HIAA/5-HT ratio (the turnover rate of 5-HT) in plasma and blood increased only in rats given stress and nicotine. These results indicate that nicotine administration may decrease stress induced increase in plasma 5-HT levels by increasing its degradation.

摘要

研究了两种应激对给予尼古丁的大鼠血浆和全血中血清素能指标的影响。电击足底应激后血浆色氨酸水平升高。给予尼古丁的大鼠施加应激后血浆色氨酸水平降低。虽然全血中5-羟色胺（5-HT）水平没有变化，但电击足底增加了血浆中5-HT水平，而束缚应激则降低了其水平。给予应激和尼古丁的大鼠血浆和全血中5-羟吲哚乙酸（5-HIAA）水平升高。仅在给予应激和尼古丁的大鼠中，血浆和血液中的5-HIAA/5-HT比值（5-HT的周转率）升高。这些结果表明，给予尼古丁可能通过增加其降解来降低应激诱导的血浆5-HT水平升高。