两性霉素B胶体分散体成功治疗隐球菌性脑膜炎：4例报告
Successful treatment of cryptococcal meningitis with amphotericin B colloidal dispersion: report of four cases.
作者信息
Valero G, Graybill J R
机构信息
Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7870, USA.
出版信息
Antimicrob Agents Chemother. 1995 Nov;39(11):2588-90. doi: 10.1128/AAC.39.11.2588.
Abstract
Four patients with cryptococcal meningitis were treated with amphotericin B colloidal dispersion because of nephrotoxicity from prior treatment with conventional amphotericin B. The limited experience presented here suggests that amphotericin B colloidal dispersion is efficacious for the treatment of cryptococcal meningitis, despite being undetectable in cerebrospinal fluid, and offers a potential therapeutic alternative for patients who cannot tolerate conventional amphotericin B.
摘要
4例隐球菌性脑膜炎患者因先前使用传统两性霉素B治疗出现肾毒性，而接受两性霉素B胶体分散体治疗。此处介绍的有限经验表明，两性霉素B胶体分散体对隐球菌性脑膜炎的治疗有效，尽管在脑脊液中检测不到，并且为不能耐受传统两性霉素B的患者提供了一种潜在的治疗选择。
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