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两性霉素B胶体分散体成功治疗隐球菌性脑膜炎：4例报告

Successful treatment of cryptococcal meningitis with amphotericin B colloidal dispersion: report of four cases.

作者信息

Valero G, Graybill J R

机构信息

Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7870, USA.

出版信息

Antimicrob Agents Chemother. 1995 Nov;39(11):2588-90. doi: 10.1128/AAC.39.11.2588.

DOI:10.1128/AAC.39.11.2588
PMID:8585754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162993/
Abstract

Four patients with cryptococcal meningitis were treated with amphotericin B colloidal dispersion because of nephrotoxicity from prior treatment with conventional amphotericin B. The limited experience presented here suggests that amphotericin B colloidal dispersion is efficacious for the treatment of cryptococcal meningitis, despite being undetectable in cerebrospinal fluid, and offers a potential therapeutic alternative for patients who cannot tolerate conventional amphotericin B.

摘要

4例隐球菌性脑膜炎患者因先前使用传统两性霉素B治疗出现肾毒性，而接受两性霉素B胶体分散体治疗。此处介绍的有限经验表明，两性霉素B胶体分散体对隐球菌性脑膜炎的治疗有效，尽管在脑脊液中检测不到，并且为不能耐受传统两性霉素B的患者提供了一种潜在的治疗选择。

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本文引用的文献

1
Treatment of cryptococcosis with liposomal amphotericin B (AmBisome) in 23 patients with AIDS.23例艾滋病患者使用两性霉素B脂质体（安必素）治疗隐球菌病。
AIDS. 1993 Jun;7(6):829-35. doi: 10.1097/00002030-199306000-00011.
2
Treatment of cryptococcal meningitis with combination amphotericin B and flucytosine for four as compared with six weeks.两性霉素B与氟胞嘧啶联合治疗隐球菌性脑膜炎四周与六周的比较。
N Engl J Med. 1987 Aug 6;317(6):334-41. doi: 10.1056/NEJM198708063170602.
3
Amphotericin B: 30 years of clinical experience.两性霉素B：30年临床经验
Rev Infect Dis. 1990 Mar-Apr;12(2):308-29. doi: 10.1093/clinids/12.2.308.
4
Efficacy and safety of amphotericin B colloidal dispersion compared with those of amphotericin B deoxycholate suspension for treatment of disseminated murine cryptococcosis.两性霉素B胶体分散体与两性霉素B脱氧胆酸盐混悬液治疗小鼠播散性隐球菌病的疗效和安全性比较
Antimicrob Agents Chemother. 1992 Dec;36(12):2656-60. doi: 10.1128/AAC.36.12.2656.