Chauffert M, Cisse A, Chevenne D, Parfait B, Michel S, Trivin F
Laboratoire de Biochimie, Foundation Hôpital Saint-Joseph, Paris, France.
Diabetes Care. 1995 May;18(5):677-80. doi: 10.2337/diacare.18.5.677.
To investigate, in Senegalese subjects, the frequency of human leukocyte antigen (HLA)-DQ beta 1 alleles and their role in susceptibility to insulin-dependent diabetes mellitus (IDDM).
HLA-DQ beta 1 typing was done in 55 IDDM subjects and 118 nondiabetic control subjects by means of polymerase chain reaction restriction fragment length polymorphism.
Alleles bearing a codon for an Asp residue at position 57 in the DQ beta-chain were associated with a significantly lower risk of IDDM. Alleles 0201 and 0302 (Ala57) were positively associated with diabetes, but allele 0501 (Val57) was less frequent in IDDM subjects than in control subjects.
HLA-DQ beta 1 alleles may be genetic susceptibility markers for IDDM in the Senegalese population, as they are in Caucasian populations.
在塞内加尔人群中研究人类白细胞抗原（HLA）-DQβ1等位基因的频率及其在胰岛素依赖型糖尿病（IDDM）易感性中的作用。
采用聚合酶链反应-限制性片段长度多态性方法，对55例IDDM患者和118例非糖尿病对照者进行HLA-DQβ1分型。
DQβ链第57位密码子为天冬氨酸残基的等位基因与IDDM风险显著降低相关。等位基因0201和0302（丙氨酸57）与糖尿病呈正相关，但等位基因0501（缬氨酸57）在IDDM患者中的频率低于对照者。
与高加索人群一样，HLA-DQβ1等位基因可能是塞内加尔人群中IDDM的遗传易感性标志物。
