Swartley J S, Stephens D S
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA.
FEMS Microbiol Lett. 1995 Dec 15;134(2-3):171-6. doi: 10.1111/j.1574-6968.1995.tb07933.x.
We report the identification of an open reading frame in a serogroup B isolate of Neisseria meningitidis that exhibits high nucleotide and predicted amino acid identity with the fpg gene of Escherichia coli, and its product, formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase), a DNA repair enzyme. We further show that the meningococcal fpg is co-transcribed with nlaA, encoding a lysophosphatidic acid acyltransferase, and suggest that the DNA repair enzyme may be involved in the regulation of nlaA or its gene product.
我们报告了在脑膜炎奈瑟菌B群分离株中鉴定出一个开放阅读框，该阅读框与大肠杆菌的fpg基因及其产物甲酰胺嘧啶-DNA糖基化酶（Fapy-DNA糖基化酶，一种DNA修复酶）具有高度的核苷酸和预测氨基酸同一性。我们进一步表明，脑膜炎球菌的fpg与编码溶血磷脂酸酰基转移酶的nlaA共转录，并提出这种DNA修复酶可能参与nlaA或其基因产物的调控。
