[脑血栓形成患者红细胞与受损内皮细胞的黏附作用]
[Adhesion of erythrocytes of patients with cerebral thrombosis to injured endothelial cells].
作者信息
Wang L, Huang X, Ding Z, Chen H, Peng R, Yuan G, Zhou D
机构信息
Biomedical Engineering Research Unit, First Affiliated Hospital.
出版信息
Hua Xi Yi Ke Da Xue Xue Bao. 1995 Sep;26(3):266-70.
Using flow chamber system, we quantitatively studied the adhesion of erythrocytes (RBCs) of patients with cerebral thrombosis (CTh) to cultured human umbilical vein endothelial cells (HUVECs) treated with H2O2. The results showed that injured HUVECs enhanced adhesion of RBCs to HUVECs in patients with CTh. There is injury of endothelial cells in the pathogenetic and pathologic process of CTh, and the adhesion of RBCs to ECs promotes vaso-occlusive and vascular damage; thus the adhesion of RBCs to injured ECs might play an important role in the pathogenesis and pathologic process of CTh.
利用流动腔系统，我们定量研究了脑血栓形成（CTh）患者红细胞（RBCs）与经过氧化氢（H2O2）处理的培养人脐静脉内皮细胞（HUVECs）的黏附情况。结果显示，受损的HUVECs增强了CTh患者RBCs与HUVECs的黏附。在CTh的发病机制和病理过程中存在内皮细胞损伤，而RBCs与内皮细胞的黏附会促进血管闭塞和血管损伤；因此，RBCs与受损内皮细胞的黏附可能在CTh的发病机制和病理过程中起重要作用。
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