人类ID1和ID2基因的染色体定位
Chromosomal assignment of human ID1 and ID2 genes.
作者信息
Mathew S, Chen W, Murty V V, Benezra R, Chaganti R S
机构信息
Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
出版信息
Genomics. 1995 Nov 20;30(2):385-7. doi: 10.1006/geno.1995.0037.
PMID:8586447
Abstract
The Id (inhibitor of DNA binding) proteins regulate transcription during development by interacting with transcription factors. Three human genes, ID1, ID2, and ID3, have been identified that belong to this family of transcription regulators. We show, by somatic cell hybridization and fluorescence in situ hybridization experiments, that ID1 and ID2 are localized at 20q11 and 2p25, respectively.
摘要
Id（DNA结合抑制因子）蛋白通过与转录因子相互作用来调控发育过程中的转录。已鉴定出三个属于该转录调节因子家族的人类基因，即ID1、ID2和ID3。我们通过体细胞杂交和荧光原位杂交实验表明，ID1和ID2分别定位于20q11和2p25。
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