肾移植和同种异体移植排斥反应后丙型慢性活动性肝炎的α干扰素治疗

Interferon alpha therapy for chronic active hepatitis type C after renal transplantation and allograft rejection.

作者信息

Takahara S, Kakimoto K, Kokado Y, Kameoka H, Ishibashi M, Kawada S, Kyo M, Nagano S, Mikami O, Okuyama A

机构信息

Department of Urology, Osaka University Medical School, Japan.

出版信息

Int Urol Nephrol. 1995;27(4):479-85. doi: 10.1007/BF02550087.

DOI:10.1007/BF02550087

PMID:8586524

Abstract

An acute type rejection episode occurred in one of two patients treated with Interferon alpha (IFN alpha) for type C hepatitis (CHC). Histopathological examination of the graft kidney revealed focal cellular infiltration and chronic transplant glomerulopathy which showed acute or chronic type rejection. In spite of bolus administration of methyl-prednisolone, the elevation of serum creatinine level continued. After administration of anti-human lymphocyte globulin (AHLG), renal function improved, but urinary protein was still positive. Another patient had no episode of rejection during or after IFN alpha therapy.

摘要

两名接受α干扰素（IFNα）治疗丙型肝炎（CHC）的患者中，有一名发生了急性排斥反应。移植肾的组织病理学检查显示局灶性细胞浸润和慢性移植肾小球病，表现为急性或慢性排斥反应。尽管给予了大剂量甲基泼尼松龙，血清肌酐水平仍持续升高。给予抗人淋巴细胞球蛋白（AHLG）后，肾功能有所改善，但尿蛋白仍为阳性。另一名患者在IFNα治疗期间及之后未发生排斥反应。