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[1990年至1994年东京进口及本土病例中分离出的志贺氏菌菌株的种类、血清型分布及耐药性]

[Species and serovar-distribution, and drug-resistance of Shigella strains isolated from imported and domestic cases from 1990 through 1994 in Tokyo].

作者信息

Matsushita S, Yamada S, Sekiguchi K, Ohta K, Kudoh Y

机构信息

Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health.

出版信息

Kansenshogaku Zasshi. 1995 Dec;69(12):1336-41. doi: 10.11150/kansenshogakuzasshi1970.69.1336.

Abstract

A total of 446 Shigella strains consisting of 336 imported and 110 domestic strains isolated in Tokyo from 1990 to 1994 were examined for their species and serovar-distribution, and their drug-resistance. In both imported and domestic strains, S. sonnei was found to be the most prevalent species, followed by S. flexneri. In imported strains, however, the isolation frequency of S. flexneri, S. boydii and S. dysenteriae were higher than that of domestic strains, and the serovar of each species was distributed in a wider range than that of the domestic strains. Provisional new serovar Shigella strains were isolated from 8 imported cases and 2 domestic cases. The drug-resistance-test using 9 drugs (CP, TC, SM, KM, ABPC, ST, NA, FOM, and NFLX) showed that 82.7% of the imported strains and 89.1% of the domestic strains were resistant to any drugs examined. Drugs of a high resistant rate were SM, TC, ST for the both groups. Drug-resistance-patterns of the resistant isolates varied to 21 types. Among those, a triple drug-resistance-type with TC SM ST was found the most frequently in both groups. None of the strains were resistant to FOM or NFLX.

摘要

对1990年至1994年在东京分离出的446株志贺氏菌菌株进行了研究,其中包括336株进口菌株和110株国内菌株,分析了它们的菌种和血清型分布以及耐药性。在进口菌株和国内菌株中,宋内志贺氏菌都是最常见的菌种,其次是福氏志贺氏菌。然而,在进口菌株中,福氏志贺氏菌、鲍氏志贺氏菌和痢疾志贺氏菌的分离频率高于国内菌株,而且每种菌种的血清型分布范围比国内菌株更广。从8例进口病例和2例国内病例中分离出了暂定的新型血清型志贺氏菌菌株。使用9种药物(氯霉素、四环素、链霉素、卡那霉素、氨苄青霉素、磺胺噻唑、萘啶酸、磷霉素和诺氟沙星)进行的耐药性测试表明,82.7%的进口菌株和89.1%的国内菌株对所检测的任何药物都有耐药性。两组中耐药率较高的药物都是链霉素、四环素和磺胺噻唑。耐药菌株中耐药模式有21种。其中,四环素-链霉素-磺胺噻唑三联耐药型在两组中最为常见。没有菌株对磷霉素或诺氟沙星耐药。

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