含59Co配合物脂质体的体内核磁共振测温法。

In-vivo NMR thermometry with liposomes containing 59Co complexes.

作者信息

Webb A G, Wong M, Niesman M, Kolbeck K J, Wilmes L J, Magin R L, Suslick K S

机构信息

Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign 61801, USA.

出版信息

Int J Hyperthermia. 1995 Nov-Dec;11(6):821-7. doi: 10.3109/02656739509052338.

DOI:10.3109/02656739509052338

PMID:8586903

Abstract

The ability to make localized temperature measurements in tissue during hyperthermia treatment of cancer is an essential factor in optimizing its efficacy. To this end we have developed and evaluated the complex tris(ethylenediamine) cobalt(III) trichloride as a temperature sensor by determining the temperature dependence of it 59Co nuclear magnetic resonance chemical shift. Encapsulating this complex within liposomes targets the agent to the reticuloendothelial system. Temperature changes of the order of 0.1 degrees C have been measured in vivo on rats, and the half-life of the complex within the body determined by plasma emission spectroscopy.

摘要

在癌症热疗过程中对组织进行局部温度测量的能力是优化其疗效的关键因素。为此，我们通过测定三氯化三（乙二胺）钴（III）配合物的59Co核磁共振化学位移对温度的依赖性，开发并评估了这种配合物作为温度传感器。将这种配合物包裹在脂质体内可使该试剂靶向网状内皮系统。已在大鼠体内测量到约0.1摄氏度的温度变化，并通过等离子体发射光谱法测定了该配合物在体内的半衰期。