Stoltz J F, Senger B, Voegel J C, Delamaire M, Schaaf P, Boisseau M
U 424 INSERM, Faculté Odontologie, Strasbourg.
J Mal Vasc. 1995;20(4):247-51.
Interactions between blood cells in the form of cellular aggregates or adhesion are observed in a variety of normal and pathological conditions. Aggregation of erythrocytes or platelets, adhesion of platelets and leucocytes and immune agglutination of RBC are examples of interactions involving blood cells. Cell adhesion and aggregation are modulated by specific interactions (antigen-antibodies reactions, adhesive macromolecules interactions...) or non-specific (van der Waals forces, electrostatic interactions, molecular bridgings...). These interactions may result in morphological and structural changes, or polarization phenomena. At the dynamic level, cellular adhesion (or aggregation) can divided in 4 main steps: transport, cellular activation (endogenous or exogenous), morphological, physical or steric rearrangements, contact (intercellular or on an artificial surfaces). It will be the nature of the interactions involved in these steps that will determine the binding cohesion and kinetic. In this paper, different types of interactions and the regulation mechanisms of adhesion and aggregation phenomena involved in blood hemodynamics will be summarized and some examples (RBC or platelets aggregation; platelets or leucocytes adhesion) will illustrate the importance of these phenomena in clinical hemorheology.
在各种正常和病理情况下，都能观察到以细胞聚集体或黏附形式存在的血细胞之间的相互作用。红细胞或血小板的聚集、血小板与白细胞的黏附以及红细胞的免疫凝集都是涉及血细胞相互作用的例子。细胞黏附和聚集受特定相互作用（抗原 - 抗体反应、黏附性大分子相互作用等）或非特异性相互作用（范德华力、静电相互作用、分子桥接等）的调节。这些相互作用可能导致形态和结构变化，或极化现象。在动态层面，细胞黏附（或聚集）可分为4个主要步骤：转运、细胞活化（内源性或外源性）、形态、物理或空间重排、接触（细胞间或在人工表面上）。正是这些步骤中所涉及的相互作用的性质决定了结合凝聚力和动力学。本文将总结血液动力学中涉及的不同类型的相互作用以及黏附与聚集现象的调节机制，并通过一些例子（红细胞或血小板聚集；血小板或白细胞黏附）来说明这些现象在临床血液流变学中的重要性。
