Hanamura A, Ichikawa A, Utsumi M, Hotta T
Department of Haematology, Gifu Prefectural Tajimi Hospital.
Rinsho Ketsueki. 1995 Dec;36(12):1347-52.
Two patients with severe aplastic anemia received combination therapy consisting of granulocyte colony-stimulating factor (G-CSF) and erythropoietin (EPO) by subcutaneous injection. During the first 8 weeks, we administered only G-CSF, but subsequently we administered EPO with G-CSF. Administration of G-CSF caused rapid increase in neutrophil counts in each case. In the first case, a 23-year-old woman, the first sign of improvement of anemia appeared in the 12th week but 50 more weeks elapsed before improvement of platelet count. In the second case, a 59-year-old woman, marked increase of reticulocytes appeared in the 32nd week, and the RBC count become normal in the 46th week. Minor improvement of platelet count was obtained in the 40th week. After 53 weeks of treatment, we stopped administration of G-CSF and EPO, and all of peripheral blood cell counts decreased. Therefore G-CSF and EPO were given to her again, and she showed the same response as first administration. It showed that she was dependent upon G-CSF and EPO. Finally she obtained normalization of all blood cell counts. In both cases, no serious side effects were observed. Combination therapy consisting of G-CSF and EPO may be beneficial for patients with aplastic anemia.
两名严重再生障碍性贫血患者接受了皮下注射粒细胞集落刺激因子（G-CSF）和促红细胞生成素（EPO）的联合治疗。在最初的8周内，我们仅给予G-CSF，但随后我们将EPO与G-CSF联合使用。在每种情况下，给予G-CSF均导致中性粒细胞计数迅速增加。在第一个病例中，一名23岁女性，贫血改善的首个迹象出现在第12周，但在血小板计数改善之前又过去了50周。在第二个病例中，一名59岁女性，网织红细胞在第32周显著增加，红细胞计数在第46周恢复正常。血小板计数在第40周有轻微改善。治疗53周后，我们停止给予G-CSF和EPO，所有外周血细胞计数均下降。因此再次给予她G-CSF和EPO，她表现出与首次给药相同的反应。这表明她依赖于G-CSF和EPO。最终她所有血细胞计数恢复正常。在这两个病例中，均未观察到严重的副作用。由G-CSF和EPO组成的联合治疗可能对再生障碍性贫血患者有益。
