Horkay F, Laine M, Szokodi I, Leppäluoto J, Vuolteenaho O, Ruskoaho H, Juhász-Nagy A, Tóth M
Department of Cardiovascular Surgery, Semmelweis Medical University, Budapest, Hungary.
J Cardiovasc Pharmacol. 1995;26 Suppl 3:S502-4.
Immunoreactive endothelin-1 (ET-1) levels were measured in the pericardial fluid (PF), plasma (PL), and atrial and ventricular tissues of 16 cardiac surgical patients. ET-1 was higher in the PF (73 +/- 11 pg/ml) than in the PL/3.33 +/- 0.51 pg/ml; p < 0.05/. PF/PL ratio ranged from 8 to as high as 200. An inverse relationship was found between the NYHA stage and ET-1 concentrations in PF, whereas ET-1 in PL did not have any relation to the NYHA stage of the disease. In HPLC analysis, the total immunoreactive ET-1 in PF from five different patients co-eluted with the human ET-1 standard. The results indicate that ET-1 concentrations in human PF can be several-fold those in the PL. The source and function of the ET-1 in PF requires further investigation.
在16例心脏手术患者的心包液（PF）、血浆（PL）以及心房和心室组织中测量了免疫反应性内皮素-1（ET-1）水平。心包液中的ET-1（73±11 pg/ml）高于血浆（3.33±0.51 pg/ml；p<0.05）。心包液/血浆比值范围为8至高达200。在心包液中发现纽约心脏协会（NYHA）心功能分级与ET-1浓度呈负相关，而血浆中的ET-1与疾病的NYHA心功能分级无关。在高效液相色谱分析中，来自五名不同患者的心包液中的总免疫反应性ET-1与人类ET-1标准品共洗脱。结果表明，人类心包液中的ET-1浓度可能是血浆中的几倍。心包液中ET-1的来源和功能需要进一步研究。
