生物样品中匹莫林的气液色谱 - 质谱联用分析

Combined gas-liquid chromatographic-mass spectrometric analysis of pemoline in biological samples.

作者信息

Van Boven M, Daenens P

出版信息

J Chromatogr. 1977 Apr 11;134(2):415-21. doi: 10.1016/s0021-9673(00)88540-4.

Abstract

A description is given of a gas-liquid chromatographic (GLC) method for the detection and determination of pemoline in biological samples. On treatment with hydrochloric acid, pemoline is converted into 5-phenyl-2,4-dioxooxazolidine, an acidic compound, which can be easily extracted with dichloromethane and determined by GLC. A combined GLC-mass spectrometric method is described.

摘要

介绍了一种用于检测和测定生物样品中匹莫林的气-液色谱（GLC）方法。用盐酸处理后，匹莫林转化为5-苯基-2,4-二氧代恶唑烷，一种酸性化合物，它可以很容易地用二氯甲烷萃取并用GLC测定。还描述了一种GLC-质谱联用方法。