γ-羟基丁酸对人体生长激素和催乳素释放的刺激作用。

Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans.

作者信息

Takahara J, Yunoki S, Yakushiji W, Yamauchi J, Yamane Y

出版信息

J Clin Endocrinol Metab. 1977 May;44(5):1014-7. doi: 10.1210/jcem-44-5-1014.

Abstract

A dose of 2.5 g of gamma-hydroxybutyric acid (GHB) was administered intravenously to 6 healthy male volunteers. A significant increase in plasma GH was observed at 30, 45, 60 and 90 min after injection. The plasma prolactin level increased significantly at 45 and 60 min after GHB injection. These responses were not found after the saline vehicle injection in the same subjects. It is conceivable that GHB could modify the release of serotonin from the nerve terminals and then stimulate the release of GH and prolactin.

摘要

向6名健康男性志愿者静脉注射2.5克γ-羟基丁酸（GHB）。注射后30、45、60和90分钟时观察到血浆生长激素（GH）显著升高。GHB注射后45和60分钟时血浆催乳素水平显著升高。在同一受试者注射生理盐水后未发现这些反应。可以想象，GHB可能会改变神经末梢中血清素的释放，进而刺激生长激素和催乳素的释放。