Bohuslavizki K H, Brenner W, Wolf H, Sippel C, Tönshoff G, Tinnemeyer S, Clausen M, Henze E
Clinic of Nuclear Medicine, Christian-Albrechts-Universität Kiel, Germany.
Nucl Med Commun. 1995 Nov;16(11):917-22. doi: 10.1097/00006231-199511000-00007.
The aim of this study was to test the impact of quantitative salivary gland scintigraphy in patients with suspected Sjögren's syndrome. Thirteen patients with suspected Sjögren's syndrome were investigated. During clinical work-up, three had severe and four had mild Sjögren's syndrome, while six were normal. Quantitative salivary gland scintigraphy was performed using a standardized method. The normal data-base consisted of 172 patients without any evidence of salivary gland malfunction. Visual and quantitative comparisons of the patients' scintigrams were made. In the patients with severe Sjögren's syndrome, uptake was 0.10 +/- 0.04% and 0.09 +/- 0.03% in the parotid and submandibular glands respectively, confirming the visual diagnosis. In the patients without Sjögren's syndrome, concordance between the visual and quantitative evaluations could also be shown. In contrast, among the patients with mild Sjögren's syndrome, uptake was diminished (P < 0.05), amounting to 0.21 +/- 0.05% and 0.16 +/- 0.02% in the parotid and submandibular glands respectively, while visual analysis indicated normal parenchymatous function. In conclusion, quantitative salivary gland scintigraphy is essential for the reliable detection of parenchymatous malfunction at an early stage of Sjögren's syndrome, which may be missed by visual analysis alone.
本研究的目的是测试定量唾液腺闪烁扫描术对疑似干燥综合征患者的影响。对13例疑似干燥综合征患者进行了调查。在临床检查过程中，3例患有重度干燥综合征，4例患有轻度干燥综合征，6例正常。采用标准化方法进行定量唾液腺闪烁扫描术。正常数据库由172例无任何唾液腺功能障碍证据的患者组成。对患者的闪烁扫描图进行了视觉和定量比较。在重度干燥综合征患者中，腮腺和颌下腺的摄取率分别为0.10±0.04%和0.09±0.03%，证实了视觉诊断。在无干燥综合征的患者中，视觉和定量评估之间也显示出一致性。相比之下，在轻度干燥综合征患者中，摄取率降低（P<0.05），腮腺和颌下腺的摄取率分别为0.21±0.05%和0.16±0.02%，而视觉分析表明实质功能正常。总之，定量唾液腺闪烁扫描术对于在干燥综合征早期可靠检测实质功能障碍至关重要，仅靠视觉分析可能会遗漏这种情况。
