Levin E D
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA.
Pharmacol Biochem Behav. 1995 Dec;52(4):837-40. doi: 10.1016/0091-3057(95)00165-s.
Antagonists of nicotinic and muscarinic acetylcholinergic (ACh) receptors have significant interactions with dopaminergic (DA) ligands with regard to radial-arm maze choice accuracy. The current studies examined the interactions of agonists of nicotinic and muscarinic ACh receptors with the DA agonist pergolide. Pergolide given in a range from 0.03-1.0 mg/kg had no detectable effect on radial-arm maze choice accuracy when given alone. With this dose range there was a linear increase in response latency. Pergolide had significant interactive effects with the nicotinic and muscarinic agonists nicotine and pilocarpine. Given together with nicotine, pergolide produced a significantly elevated linear increase in accuracy relative to when it was given alone. With pilocarpine, pergolide had an inverted U-shaped effect improving choice accuracy at low to moderate doses of 0.03 and 0.1 mg/kg. These results support previous findings of DA-ACh interactions with regard to radial-arm maze choice accuracy. Combined DA-ACh treatment may be a useful treatment of cognitive dysfunction.
就放射状臂迷宫选择准确性而言，烟碱型和毒蕈碱型乙酰胆碱能（ACh）受体拮抗剂与多巴胺能（DA）配体有显著相互作用。当前研究考察了烟碱型和毒蕈碱型ACh受体激动剂与DA激动剂培高利特的相互作用。单独给予0.03 - 1.0 mg/kg剂量范围的培高利特时，对放射状臂迷宫选择准确性无明显可检测到的影响。在此剂量范围内，反应潜伏期呈线性增加。培高利特与烟碱型和毒蕈碱型激动剂尼古丁和毛果芸香碱有显著的相互作用。与尼古丁合用时，相对于单独给药，培高利特使准确性的线性增加显著提高。与毛果芸香碱合用时，培高利特在0.03和0.1 mg/kg的低至中等剂量时有倒U形效应，可提高选择准确性。这些结果支持了先前关于DA - ACh在放射状臂迷宫选择准确性方面相互作用的研究发现。联合DA - ACh治疗可能是治疗认知功能障碍的有效方法。
