5-羟色胺1A受体激动剂8-羟基二丙基氨基四氢萘（8-OH-DPAT）对猪操作性进食的影响。
Effects of the 5-HT1A agonist 8-OH-DPAT on operant feeding in pigs.
作者信息
Baldwin B A, de la Riva C
机构信息
AFRC Babraham Institute, Cambridge.
出版信息
Physiol Behav. 1995 Sep;58(3):611-3. doi: 10.1016/0031-9384(95)00014-a.
The effect of intravenous (i.v.) injection of 8-OH-DPAT on operant food intake in pigs has been examined in animals with food available ad lib and in pigs feeding after 4 h deprivation of food. Operant methods were used to ascertain whether any increases in food intake were due to increased motivation to feed rather than stereotypic chewing movements. In nondeprived animals i.v. injection of 8-OH-DPAT at doses of 10, 30, and 50 micrograms/kg significantly increased food intake in the 45 min following injection. In pigs feeding after 4 h deprivation, i.v. injection of 8-OH-DPAT at doses of 30 and 50 micrograms/kg, given 5 min before feeding commenced, had no effect on food intake.
已在不限量供应食物的动物以及禁食4小时后进食的猪身上，研究了静脉注射8-羟基二丙胺对猪操作性食物摄入量的影响。采用操作性方法来确定食物摄入量的任何增加是否是由于进食动机增强而非刻板咀嚼动作所致。在未禁食的动物中，静脉注射剂量为10、30和50微克/千克的8-羟基二丙胺，在注射后的45分钟内显著增加了食物摄入量。在禁食4小时后进食的猪中，在进食开始前5分钟静脉注射剂量为30和50微克/千克的8-羟基二丙胺，对食物摄入量没有影响。
Zotero 插件