Saadoun A, Cabrera M C
Laboratorio de Fisiología y Fisiopatología de la Nutricion, Seccion Fisiología y Nutricion, Facultad de Ciencias, Calle Igua 4225, 11400, Montevideo, Uruguay.
Physiol Behav. 2002 Mar;75(3):271-5. doi: 10.1016/s0031-9384(01)00665-5.
The effects of the 5-HT(1A) receptor agonist 8-OH-DPAT on food and water intake in 16-week-old male chickens were investigated. Injection of 25 or 50 microg/kg of 8-OH-DPAT 15 min before refeeding starved animals (starved-refed) produced a decrease in food intake 1 h after the start of refeeding. No effect was observed in water intake. The injection of 25 or 50 microg/kg of the 8-OH-DPAT 60 min after the start of refeeding (fed) produced increased food intake, but no effect was observed on water intake. The agonist 8-OH-DPAT (50 microg/kg) injected in water-deprived chickens 15 min before water presentation produced a rapid increase in water intake and an increase in food intake 90 min after the presentation of water. The effect on food intake was mainly apparent 60-90 min after injection. However, when the chickens were water-deprived, the intravenous administration of 8-OH-DPAT 15 min before the presentation of water produced an increase in water intake only 15 min after the start of the experiment. The results show that the effect on food intake of the agonist 8-OH-DPAT in chickens was similar to that observed in mammals. Also, the results show that the agonist-induced increase in water intake may act via a different mechanism. The results show that the 8-OH-DPAT, as in mammals, has a complex effect on food and water intake in chickens and that further works need to be carried out to understand the mechanisms involved in the food and water intake using different animal models.
研究了5-羟色胺（5-HT）（1A）受体激动剂8-羟基二丙胺基四氢萘（8-OH-DPAT）对16周龄雄性鸡食物和水摄入量的影响。在给饥饿动物重新喂食（饥饿-再喂食）前15分钟注射25或50微克/千克的8-OH-DPAT，在重新喂食开始1小时后食物摄入量减少。未观察到对水摄入量的影响。在重新喂食开始60分钟后（喂食状态）注射25或50微克/千克的8-OH-DPAT会使食物摄入量增加，但对水摄入量未观察到影响。在给水剥夺的鸡提供水之前15分钟注射激动剂8-OH-DPAT（50微克/千克），会使水摄入量迅速增加，并在提供水90分钟后食物摄入量增加。对食物摄入量的影响主要在注射后60-90分钟明显。然而，当鸡处于水剥夺状态时，在提供水之前15分钟静脉注射8-OH-DPAT，仅在实验开始15分钟后水摄入量就增加了。结果表明，激动剂8-OH-DPAT对鸡食物摄入量的影响与在哺乳动物中观察到的相似。此外，结果表明激动剂诱导的水摄入量增加可能通过不同机制起作用。结果表明，与哺乳动物一样，8-OH-DPAT对鸡的食物和水摄入量有复杂影响，需要进一步开展工作以利用不同动物模型了解食物和水摄入所涉及的机制。
