Hirschberger J, Koch S
First Medical Veterinary Clinic of the University of Munich, Germany.
Res Vet Sci. 1995 Nov;59(3):226-9. doi: 10.1016/0034-5288(95)90007-1.
In order to identify parameters differentiating exudative from transudative effusions, it was postulated that the activity of adenosine deaminase (AD) (EC 3.5.4.4) might be highly correlated with granulomatous inflammatory processes of the serosa, and the activity of the enzyme in body effusions and serum from cats was examined. The method of Slaats et al (1985) for the determination of the enzyme was evaluated by using an Hitachi 705 autoanalyser, and its activity was measured in body cavity effusions of 174 cats. The activity of AD was high in effusions from cats with infectious serositis and bacterial or feline infectious peritonitis (FIP). In cases of FIP the activity of AD was very significantly different from all other cases of thoracic (P = 0.004) and abdominal (P < 0.0001) effusions. The determination of AD in the serum of cats did not contribute to the aetiological differentiation of hydrops. The increases in the activity of AD appeared to originate from the body effusion, because the ratio of the activity of the enzyme in the effusion to its activity in serum was relatively high in cases of FIP.
为了确定区分渗出液和漏出液的参数，有人推测腺苷脱氨酶（AD）（EC 3.5.4.4）的活性可能与浆膜的肉芽肿性炎症过程高度相关，并对猫体腔积液和血清中的该酶活性进行了检测。使用日立705自动分析仪对Slaats等人（1985年）测定该酶的方法进行了评估，并在174只猫的体腔积液中测量了其活性。患有传染性浆膜炎、细菌性或猫传染性腹膜炎（FIP）的猫的积液中AD活性较高。在FIP病例中，AD活性与所有其他胸腔积液（P = 0.004）和腹腔积液（P < 0.0001）病例有非常显著差异。测定猫血清中的AD对水肿的病因鉴别没有帮助。AD活性的升高似乎源于体腔积液，因为在FIP病例中，积液中该酶的活性与其血清活性的比值相对较高。
