Orlov S N, Li J M, Tremblay J, Hamet P
Centre de Recherche, Hôtel-Dieu de Montréal, Université de Montréal, Québec, Canada.
Semin Nephrol. 1995 Nov;15(6):569-92.
In the last two decades, major progress has been made in understanding the role of calcium (Ca) metabolism in blood pressure (BP) control. This article discusses the intracellular Ca handling systems that could potentially be involved in the pathogenesis of primary hypertension. We begin by reviewing our current knowledge of intracellular Ca handling, alterations of intracellular Ca metabolism in primary hypertension, and possible mechanisms of BP control. We have analyzed data on the structure and alternative splicing of major genes controlling intracellular free Ca concentration, ie, genes encoding intracellular Ca-binding protein (calmodulin, calbindin, plasma membrane Ca2+ pump, Na+/Ca2+ exchanger, and voltage-dependent Ca channels). Data are presented on the relationship of gene polymorphism and alternative splicing with membrane architecture and the function of gene products. Numerous observations on abnormalities of these gene products in primary hypertension are summarized. Studies on the polymorphism of genes regulating intracellular Ca in hypertension are only now being performed.
在过去二十年里，在理解钙（Ca）代谢在血压（BP）控制中的作用方面取得了重大进展。本文讨论了可能参与原发性高血压发病机制的细胞内钙处理系统。我们首先回顾一下我们目前对细胞内钙处理、原发性高血压中细胞内钙代谢的改变以及血压控制的可能机制的认识。我们分析了控制细胞内游离钙浓度的主要基因的结构和可变剪接数据，即编码细胞内钙结合蛋白（钙调蛋白、钙结合蛋白、质膜Ca2+泵、Na+/Ca2+交换器和电压依赖性钙通道）的基因。文中展示了基因多态性和可变剪接与膜结构以及基因产物功能之间的关系。总结了关于原发性高血压中这些基因产物异常的大量观察结果。目前才开始进行关于高血压中调节细胞内钙的基因多态性的研究。
