Cavanaugh J M, Kallakuri S, Ozaktay A C
Bioengineering Center, Wayne State University, Detroit, Michigan, USA.
Spine (Phila Pa 1976). 1995 Oct 1;20(19):2080-5. doi: 10.1097/00007632-199510000-00002.
The present study sought to determine to what extent the lumbar intervertebral disc and posterior longitudinal ligament are innervated in the New Zealand white rabbit. The intent is to use this disc model in future neurophysiology studies.
To characterize the distribution of nerve fibers and endings in the lumbar intervertebral disc and posterior longitudinal ligament in an animal model.
The results of previous disc innervation reports are somewhat conflicting regarding the density and depth of innervation into the anulus.
A silver impregnation technique was used to analyze sections from lumbar intervertebral disc and posterior longitudinal ligament of the New Zealand white rabbit.
Numerous fine profiles of nerve fibers were demonstrated in the lumbar disc anulus and posterior longitudinal ligament. In the disc, the nerves were limited to the superficial anulus and anular surface. The nerve axons typically were 1 to 3 microns in diameter and were found around the entire periphery of the disc. No encapsulated endings were seen within the anulus, while occasional encapsulated endings were seen on the anular surface and posterior longitudinal ligament.
This study demonstrates an extensive distribution of small nerve fibers in the size range of C and A-delta fibers throughout the peripheral anulus and provides an illustration of this distribution. These findings support a role for the disc as a source of low back pain.
本研究旨在确定新西兰白兔腰椎间盘和后纵韧带的神经支配程度。目的是在未来的神经生理学研究中使用这种椎间盘模型。
在动物模型中描述腰椎间盘和后纵韧带中神经纤维和神经末梢的分布特征。
先前关于椎间盘神经支配的报告结果在纤维环神经支配的密度和深度方面存在一定冲突。
采用银浸染技术分析新西兰白兔腰椎间盘和后纵韧带的切片。
在腰椎间盘纤维环和后纵韧带中发现了大量神经纤维的精细轮廓。在椎间盘中，神经局限于纤维环浅层和纤维环表面。神经轴突直径通常为1至3微米，分布在椎间盘的整个周边。在纤维环内未见被膜包裹的神经末梢，而在纤维环表面和后纵韧带上偶尔可见被膜包裹的神经末梢。
本研究表明，在整个外周纤维环中广泛分布着C类和A-δ类纤维大小范围内的小神经纤维，并给出了这种分布的图示。这些发现支持椎间盘作为下腰痛来源的作用。
