Holt D W, Johnston A
Analytical Unit, St. George's Hospital Medical School, London, England.
Ther Drug Monit. 1995 Dec;17(6):625-30. doi: 10.1097/00007691-199512000-00014.
The majority of centres measuring cyclosporine have followed the advice of previous consensus meetings. Although most measurements are made using assays with a high specificity for the parent compound, there are still some between-method differences that can be attributed to methodological variables, such as antibody specificity and assay calibration. With experience of cyclosporine therapeutic drug monitoring (TDM) now spanning 15 years, it would be reasonable to infer that the subject is incapable of growth. However, continued interest in the pharmacokinetics of cyclosporine, the introduction of a new formulation of the drug, and the development of new immunosuppressive agents all combine to emphasise the still incomplete extent of our knowledge in this field.
大多数检测环孢素的中心都遵循了以往共识会议的建议。尽管大多数检测是使用对母体化合物具有高特异性的分析方法进行的，但方法之间仍存在一些差异，这些差异可归因于方法学变量，如抗体特异性和分析校准。鉴于环孢素治疗药物监测（TDM）的经验现已跨越15年，可以合理推断该研究对象无法生长。然而，对环孢素药代动力学的持续关注、该药物新剂型的推出以及新型免疫抑制剂的开发，都共同强调了我们在这一领域的知识仍不完整。
