Wohlsein P, Wamwayi H M, Trautwein G, Pohlenz J, Liess B, Barrett T
Institute of Pathology, School of Veterinary Medicine, Hannover, Germany.
Vet Microbiol. 1995 May;44(2-4):141-9. doi: 10.1016/0378-1135(95)00007-w.
Experimental infection of nine cattle with seven rinderpest virus strains of different pathogenicity resulted in significant variations of clinical signs, morphological lesions and distribution of viral antigen in tissues. The severity of clinical disease was correlated with the extent of tissue alterations and the amount of immunohistologically detectable viral antigen. Both mild and virulent strains of rinderpest share essentially the same tissue tropisms in vivo, i.e. epithelio- and lympho-tropism. However, rinderpest virus isolates of higher pathogenicity showed a more rapid and wider distribution with more extensive lesions than milder strains, which probably accounts for the higher mortality.
用七种不同致病性的牛瘟病毒株对九头牛进行实验性感染，结果导致临床症状、形态学损伤以及病毒抗原在组织中的分布出现显著差异。临床疾病的严重程度与组织改变的程度以及免疫组织化学可检测到的病毒抗原量相关。牛瘟的温和毒株和强毒株在体内基本具有相同的组织嗜性，即上皮嗜性和淋巴嗜性。然而，致病性较高的牛瘟病毒分离株比温和毒株显示出更快速、更广泛的分布以及更广泛的损伤，这可能是导致更高死亡率的原因。
