一只患有IgA型多发性骨髓瘤的犬出现伴有两种M成分的丙种球蛋白病。

Gammopathy with two M-components in a dog with IgA-type multiple myeloma.

作者信息

Kato H, Momoi Y, Omori K, Youn H Y, Yamada T, Goto N, Ono K, Watari T, Tsujimoto H, Hasegawa A

机构信息

Department of Veterinary Internal Medicine, Faculty of Agriculture, University of Tokyo, Japan.

出版信息

Vet Immunol Immunopathol. 1995 Nov;49(1-2):161-8. doi: 10.1016/0165-2427(95)05462-f.

DOI:10.1016/0165-2427(95)05462-f

PMID:8588338

Abstract

A 12-year neutered male mixed-breed dog was referred to hospital for evaluation of chronic diarrhea. Cellulose acetate electrophoresis of its serum revealed two monoclonal peaks in the gamma-globulin fraction. On immunoelectrophoretic analysis, the two monoclonal peaks in the gamma-globulin region were strongly precipitated with anti-dog IgA serum. On sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis, the fractions corresponding to these two peaks were shown to be dimer and trimer or tetramer of immunoglobulin consisting of heavy and light chains. These results indicated that the studied dog had gammopathy with two M-components with dimer and trimer or tetramer of IgA. Accumulations of large amounts of these immunoglobulins with very high molecular weight in the serum were concluded to induce the hyperviscosity syndrome in this dog in the terminal stage.

摘要

一只12岁已绝育的雄性混种犬因慢性腹泻被转诊至医院评估。其血清的醋酸纤维素电泳显示在γ球蛋白部分有两个单克隆峰。免疫电泳分析显示，γ球蛋白区域的这两个单克隆峰与抗犬IgA血清强烈沉淀。在十二烷基硫酸钠-聚丙烯酰胺凝胶电泳分析中，对应这两个峰的组分显示为由重链和轻链组成的免疫球蛋白二聚体、三聚体或四聚体。这些结果表明，所研究的犬患有伴有两种M成分（IgA二聚体和三聚体或四聚体）的丙种球蛋白病。血清中大量此类高分子量免疫球蛋白的蓄积被认为在该犬的终末期诱发了高黏滞综合征。