Schiek M, Drepper F R, Abel H H
AG Modellierung für Umweltforschung und Lebenswissenschaften, Jülich, Deutschland.
Wien Med Wochenschr. 1995;145(17-18):492-4.
We developed a mathematical model of "respiratory" sinus arrhythmia. The model combines a representation continuous in time of the parasympathetic and sympathetic innervation and the membrane potential of the pace maker cell of the heart with a beat-by-beat representation of the cardiovascular variables like diastolic and systolic blood pressure, pulse pressure, total peripheral resistance and baroreceptor activity. The influence of respiration is described separately by mechanical and central neural mechanisms. Using this nonlinear model of "respiratory" heart rate variability one is able to explore in a theoretical way the different heart rate variability generating mechanisms, either as isolated or combined effects on both, heart rate variability in the frequency range of respiration and in the frequency range around 0.1 Hz. By fitting a simulated RR interval time course to a physiological RR interval time course one can estimate the relative weight of the different mechanisms generating this physiological heart rate variability.
我们建立了一个“呼吸性”窦性心律失常的数学模型。该模型将副交感神经和交感神经支配以及心脏起搏细胞的膜电位随时间的连续表示与心血管变量（如舒张压和收缩压、脉压、总外周阻力和压力感受器活动）的逐搏表示相结合。呼吸的影响通过机械和中枢神经机制分别描述。使用这个“呼吸性”心率变异性的非线性模型，人们能够从理论上探索不同的心率变异性产生机制，无论是对呼吸频率范围内和0.1Hz左右频率范围内的心率变异性的单独影响还是综合影响。通过将模拟的RR间期时间进程与生理RR间期时间进程进行拟合，可以估计产生这种生理性心率变异性的不同机制的相对权重。
