Hampe S, Haen E, Emslander H P
Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität, München, Deutschland.
Wien Med Wochenschr. 1995;145(17-18):501-2.
Plasma samples from 5 asthma patients were taken in 4-h intervals before and 1, 2, 4 and 6 h after the oral application of 100 mg methylprednisolone. Reversed-phase HPLC allowed simultaneous measurement of both endogenous hydrocortisone and exogeneous methylprednisolone. Suppression of endogeneous hydrocortisone secretion occurs immediately after administration of a single oral dose of an exogeneous glucocorticoid and cannot be avoided by morning application.
在口服100毫克甲泼尼龙之前以及之后1、2、4和6小时，以4小时的间隔采集5名哮喘患者的血浆样本。反相高效液相色谱法可同时测定内源性氢化可的松和外源性甲泼尼龙。单次口服外源性糖皮质激素后，内源性氢化可的松分泌立即受到抑制，且早晨用药也无法避免这种情况。
