Palevsky P M, Burr R, Moreland L, Tokiwa Y, Greenberg A
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA.
ASAIO J. 1995 Oct-Dec;41(4):847-9.
Clotting of the extracorporeal circuit during continuous renal replacement therapy results in decreased ultrafiltration rates, impaired solute clearance and, ultimately, occlusion of the extracorporeal circuit. The authors conducted an open-label randomized controlled trial to determine whether low molecular weight dextran could prevent hemofilter clotting in patients undergoing continuous venovenous hemodialysis. Eleven patients were randomized to receive a continuous infusion of 10% low molecular weight dextran at 25 mL/hr; 8 patients served as control subjects. No differences in the frequency of hemofilter clotting or hemofilter lifespan were detected. The authors concluded that continuous infusion of low dose low molecular weight dextran is not effective in preventing clotting during continuous renal replacement therapy.
在持续肾脏替代治疗期间，体外循环的凝血会导致超滤率降低、溶质清除受损，并最终导致体外循环阻塞。作者进行了一项开放标签随机对照试验，以确定低分子量右旋糖酐是否能预防接受持续静静脉血液透析患者的血液滤过器凝血。11名患者被随机分配接受以25毫升/小时的速度持续输注10%低分子量右旋糖酐；8名患者作为对照。未检测到血液滤过器凝血频率或血液滤过器使用寿命的差异。作者得出结论，在持续肾脏替代治疗期间持续输注低剂量低分子量右旋糖酐对预防凝血无效。
