Klink M, Rudnicka W
Microbiology and Virology Centre, Polish Academy of Sciences, Lodz, Poland.
FEMS Immunol Med Microbiol. 1995 Oct;12(2):143-52. doi: 10.1111/j.1574-695X.1995.tb00186.x.
Pregnant A/J mice were found to be more susceptible to the lethal effect of Listeria monocytogenes bacteria than virgin females. However, during the first four days of post-infection there was no difference in the elimination of Listeria from the spleens of pregnant and virgin mice. This suggests that the increase in the susceptibility of pregnant mice to pathogenic activity of L. monocytogenes was related to the diminution in Listeria-specific cellular reactions. Indeed, we found that non-adherent light density dendritic cells (DCs) from pregnant mice showed a marked reduction in the ability to form clusters with L. monocytogenes immune T lymphocytes and it is known that cell cluster formation between antigen presenting cells (APC) and responding T cells is required for antigen recognition as well as for cell proliferation. DCs from pregnant mice also demonstrated the decrease and an instability in the expression of H-2 class II molecules which play a crucial role in the recognition of exogenous antigens. The abnormalities demonstrated in the function of the light density dendritic cells from the spleens of pregnant mice could compromise cellular reactions to L. monocytogenes bacteria possibly resulting in increased susceptibility of pregnant mice to experimental listeriosis.
研究发现，怀孕的A/J小鼠比未孕雌性小鼠更容易受到单核细胞增生李斯特菌的致死作用影响。然而，在感染后的头四天，怀孕小鼠和未孕小鼠脾脏中李斯特菌的清除情况并无差异。这表明，怀孕小鼠对单核细胞增生李斯特菌致病活性易感性的增加与李斯特菌特异性细胞反应的减弱有关。事实上，我们发现怀孕小鼠的非黏附低密度树突状细胞（DCs）与单核细胞增生李斯特菌免疫T淋巴细胞形成簇的能力显著降低，而且已知抗原呈递细胞（APC）与反应性T细胞之间的细胞簇形成是抗原识别以及细胞增殖所必需的。怀孕小鼠的DCs还表现出H-2 II类分子表达的减少和不稳定性，而H-2 II类分子在外源抗原的识别中起关键作用。怀孕小鼠脾脏中低密度树突状细胞功能所表现出的异常可能会损害对单核细胞增生李斯特菌的细胞反应，从而可能导致怀孕小鼠对实验性李斯特菌病的易感性增加。
