Abram M, Dorić M
Department of Microbiology, Medical Faculty, University of Rijeka, Croatia.
Folia Microbiol (Praha). 1997;42(1):65-71. doi: 10.1007/BF02898648.
The facultative intracellular Gram-positive bacterium Listeria monocytogenes is a food-borne pathogen of frequently underestimated importance. Pregnant women represent the high-risk group for L. monocytogenes infection. Abortion, stillbirth or neonatal infection can be the serious outcome of such an infection. Recovery from listeriosis, resistance mechanisms of the host and the effect of L. monocytogenes on fetal development still remain to be fully understood. The results of our experiments showed an increased susceptibility of gestating BALB/c mice to primary L. monocytogenes infection. The duration of listeriosis in gestating animals was almost twice longer than in the control group. Furthermore, it was clearly shown that the detrimental effect of L. monocytogenes on fetal development was more pronounced if the infection was acquired earlier during gestation.
兼性细胞内革兰氏阳性菌单核细胞增生李斯特菌是一种重要性常被低估的食源性病原体。孕妇是单核细胞增生李斯特菌感染的高危人群。流产、死产或新生儿感染可能是此类感染的严重后果。关于李斯特菌病的康复、宿主的抵抗机制以及单核细胞增生李斯特菌对胎儿发育的影响仍有待充分了解。我们的实验结果表明，妊娠BALB/c小鼠对原发性单核细胞增生李斯特菌感染的易感性增加。妊娠动物患李斯特菌病的持续时间几乎是对照组的两倍。此外，还清楚地表明，如果在妊娠早期感染，单核细胞增生李斯特菌对胎儿发育的有害影响会更加明显。
