表皮生长因子/转化生长因子-α家族及其受体。

The epidermal growth factor/transforming growth factor-alpha family and their receptors.

作者信息

Brown K D

机构信息

Babraham Institute, Cambridge, UK.

出版信息

Eur J Gastroenterol Hepatol. 1995 Oct;7(10):914-22. doi: 10.1097/00042737-199510000-00002.

DOI:10.1097/00042737-199510000-00002

PMID:8590134

Abstract

Cytokines and growth factors act as intercellular signalling molecules which control cellular functions during development and in response to injury or infection. The epidermal growth factor (EGF) family is an expanding group of structurally related polypeptides that regulate cell proliferation, migration and differentiation, via tyrosine kinase receptors on target cells. This chapter reviews recent developments in the characterization of EGF family members and their receptors.

摘要

细胞因子和生长因子作为细胞间信号分子，在发育过程中以及对损伤或感染作出反应时控制细胞功能。表皮生长因子（EGF）家族是一组不断扩大的结构相关多肽，它们通过靶细胞上的酪氨酸激酶受体调节细胞增殖、迁移和分化。本章综述了表皮生长因子家族成员及其受体特征的最新进展。