转化生长因子-α及相关肽的基本作用。

Basic actions of transforming growth factor-alpha and related peptides.

作者信息

Coffey R J, Gangarosa L M, Damstrup L, Dempsey P J

机构信息

Department of Medicine, Vanderbilt University, Nashville, TN 37232-2279, USA.

出版信息

Eur J Gastroenterol Hepatol. 1995 Oct;7(10):923-7. doi: 10.1097/00042737-199510000-00003.

DOI:10.1097/00042737-199510000-00003

PMID:8590135

Abstract

Transforming growth factor-alpha (TGF-alpha) and related peptides have been implicated in a wide range of biological activities, including cell growth, differentiation and acid inhibition. This chapter reviews the roles of TGF-alpha in the stomach, the insights gained into the action of the TGF-alpha family of growth factors from the study of polarized epithelial cells and the confirmation of events mediated by the epidermal growth factor receptor (EGFR) by the study of mice in which the EGFR has been disrupted by homologous recombination.

摘要

转化生长因子-α（TGF-α）及相关肽参与了广泛的生物学活性，包括细胞生长、分化和胃酸抑制。本章综述了TGF-α在胃中的作用，通过对极化上皮细胞的研究深入了解了TGF-α生长因子家族的作用，以及通过对表皮生长因子受体（EGFR）因同源重组而被破坏的小鼠的研究，证实了由EGFR介导的事件。