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田旋花(Convolvulus arvensis)对小鼠的毒性

Toxicity of field bindweed (Convolvulus arvensis) to mice.

作者信息

Schultheiss P C, Knight A P, Traub-Dargatz J L, Todd F G, Stermitz F R

机构信息

Department of Pathology, Colorado State University, Fort Collins 80523, USA.

出版信息

Vet Hum Toxicol. 1995 Oct;37(5):452-4.

PMID:8592835
Abstract

The effects of feeding high and low doses of field bindweed (Convolvulus arvensis) to mice were investigated. Bindweed contains several alkaloids, including pseudotropine, and lesser amounts of tropine, tropinone, and meso-cuscohygrine. Mice fed bindweed exclusively died or were euthanized after 4-7 d and had severe hepatic necrosis and gastritis with ulceration or erosions. Mice fed low doses of bindweed along with standard laboratory mouse diet for 6 or 8 w had no clinical disease or gross lesions on necropsy examination but did have histologic lesions of mild multifocal hepatitis and gastritis.

摘要

研究了给小鼠喂食高剂量和低剂量田旋花(Convolvulus arvensis)的效果。田旋花含有多种生物碱,包括假托品,以及少量的托品、托品酮和中消旋古柯碱。只喂食田旋花的小鼠在4 - 7天后死亡或被安乐死,并有严重的肝坏死和伴有溃疡或糜烂的胃炎。喂食低剂量田旋花并同时给予标准实验室小鼠饲料6周或8周的小鼠,尸检时没有临床疾病或肉眼可见病变,但有轻度多灶性肝炎和胃炎的组织学病变。

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