Furue M, Suzuki H, Kodama T, Hiramoto T, Sugiyama H, Tamaki K
Department of Dermatology, Yamanashi Medical University, Japan.
J Dermatol Sci. 1995 Nov;10(3):213-9. doi: 10.1016/0923-1811(95)00406-i.
Verruciform xanthoma is a rare variant of xanthoma that appears predominantly on oral mucosa and the anogenital area. The histologic features are characterized by marked accumulation of foam cells in the papillary dermis with verrucous epidermal acanthosis and hyperkeratosis. However, little is known of the nature or origin of foam cells. Recent studies have emphasized the crucial role of macrophage scavenger receptors in the formation of foam cells in atherogenesis. We examined the immunohistologic localization of scavenger receptors in genital verruciform xanthoma. We found that the massively infiltrated foam cells in the papillary dermis were CD68+ monocyte-macrophage lineage cells, and that the majority of CD68+ cells coexpressed scavenger receptors. The in situ staining pattern of scavenger receptor in foam cells was mainly of an intracytoplasmic vacuolar pattern similar to that of dermal resident macrophages found in normal skin. Furthermore, CD1a+ Langerhans cells, completely negative for scavenger receptor, were markedly decreased in number in verruciform xanthoma. These results indicate that scavenger receptor-bearing CD68+ cells are also actively involved in the development of cutaneous verruciform xanthoma, as has been shown to be the case in atherogenesis.
疣状黄色瘤是黄色瘤的一种罕见变体，主要出现在口腔黏膜和肛门生殖器区域。其组织学特征表现为乳头真皮层中泡沫细胞显著积聚，伴有疣状表皮棘皮症和角化过度。然而，关于泡沫细胞的性质或来源知之甚少。最近的研究强调了巨噬细胞清道夫受体在动脉粥样硬化形成过程中泡沫细胞形成中的关键作用。我们检查了清道夫受体在生殖器疣状黄色瘤中的免疫组织学定位。我们发现，乳头真皮层中大量浸润的泡沫细胞是CD68 +单核细胞 - 巨噬细胞谱系细胞，并且大多数CD68 +细胞共表达清道夫受体。泡沫细胞中清道夫受体的原位染色模式主要是胞质内空泡模式，类似于正常皮肤中发现的真皮驻留巨噬细胞。此外，清道夫受体完全阴性的CD1a +朗格汉斯细胞在疣状黄色瘤中的数量明显减少。这些结果表明，携带清道夫受体的CD68 +细胞也积极参与皮肤疣状黄色瘤的发展，正如在动脉粥样硬化中所显示的那样。
