Scott J J, Davies P, Petit J
Department of Cell Physiology and Pharmacology, University of Leicester, UK.
Brain Res. 1995 Oct 30;697(1-2):225-34. doi: 10.1016/0006-8993(95)00847-j.
An investigation has been carried out into the physiological properties of tendon organs and their interactions with motor units following two types of nerve injury: nerve crush and nerve transection followed by suture repair. Recovery from nerve crush was very successful: 6 weeks after the injury 60% of the tendon organ-motor unit interactions (n = 62) evoked normal or near-normal patterns of afferent discharge but with reduced firing rates. After 10 weeks of recovery 81% of the interactions (n = 43) were normal. The main abnormality observed was a phasic-only pattern of discharge. The overall reductions in firing rate during early recovery may be attributable to the lower contractile forces generated by the reinnervated muscle units, while the phasic-only responses may also represent immaturity of the transduction mechanism of the regenerated afferent axons. Following nerve transection the quality of recovery was much lower and a range of abnormal, as well as normal patterns of response were observed. For all the afferents studied, both types of response were recorded, suggesting that although there may be changes in the sensitivity of the afferents to muscle contraction, the abnormal responses more probably reflect changes in the form of the mechanical input rather than abnormalities of the transduction process.
神经挤压伤和神经切断后缝合修复。神经挤压伤的恢复非常成功：损伤后6周，60%的肌腱器官 - 运动单位相互作用（n = 62）诱发了正常或接近正常的传入放电模式，但放电频率降低。恢复10周后，81%的相互作用（n = 43）正常。观察到的主要异常是仅呈相位性的放电模式。早期恢复期间放电频率的总体降低可能归因于再支配的肌肉单位产生的收缩力较低，而仅呈相位性的反应也可能代表再生传入轴突转导机制的不成熟。神经切断后恢复质量要低得多，观察到一系列异常以及正常的反应模式。对于所有研究的传入神经，两种反应类型均有记录，这表明尽管传入神经对肌肉收缩的敏感性可能发生变化，但异常反应更可能反映机械输入形式的变化而非转导过程的异常。
