重新审视新生儿耐受性：利用树突状细胞激活新生T细胞。

Neonatal tolerance revisited: turning on newborn T cells with dendritic cells.

作者信息

Ridge J P, Fuchs E J, Matzinger P

机构信息

Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Science. 1996 Mar 22;271(5256):1723-6. doi: 10.1126/science.271.5256.1723.

DOI:10.1126/science.271.5256.1723

PMID:8596932

Abstract

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.

摘要

一段时间以来，人们一直认为新生儿期的抗原刺激是一种诱导免疫耐受而非免疫原性的事件。对比林厄姆、布伦特和梅达沃经典的新生儿耐受实验后发现，耐受并非新生儿免疫系统的固有特性，而是抗原呈递细胞的性质决定了结果是新生儿耐受还是免疫。