新生儿对同种异体抗原的耐受性会改变主要组织相容性复合体限制的反应模式。
Neonatal tolerance to alloantigens alters major histocompatibility complex-restricted response patterns.
作者信息
Müllbacher A
出版信息
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7689-91. doi: 10.1073/pnas.78.12.7689.
Abstract
Male-specific transplantation antigen (H-Y)-immune cytotoxic T cells of some individual CBA/H mice exhibit lytic activity on male and female allogeneic targets (e.g., H-2b). Neonatal tolerance to H-2b abrogates the ability of CBA mice to generate secondary H-Y-immune cytotoxic T cells, but such cell activity to third-party alloantigens and to Bebaru and influenza virus is not impaired. The results are discussed in relationship to dominant major histocompatibility complex-coded immune response gene effects on cytotoxic T-cell responses.
摘要
一些CBA/H品系雄性小鼠的雄性特异性移植抗原（H-Y）免疫细胞毒性T细胞，对雄性和雌性同种异体靶细胞（如H-2b）具有裂解活性。新生期对H-2b的耐受性消除了CBA小鼠产生继发性H-Y免疫细胞毒性T细胞的能力，但这种细胞对第三方同种异体抗原以及对贝巴鲁病毒和流感病毒的活性并未受损。本文结合主要组织相容性复合体编码的显性免疫反应基因对细胞毒性T细胞反应的影响对这些结果进行了讨论。
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本文引用的文献
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Alloreactivity of an antigen-specific T-cell clone.抗原特异性T细胞克隆的同种异体反应性。
Nature. 1980 Oct 30;287(5785):855-7. doi: 10.1038/287855a0.
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