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极低出生体重儿(<1501克)两岁时的神经发育

[Neurological development of very low birth weight infants (<1,501 gr) at two ears of age].

作者信息

Gassió R, Monsó G, Póo P, Navarro A, Iriondo M, Ibáñez M, Campistol J, Krauel X

机构信息

Servicio de Neuropediatria, Hospital de Sant Joan de Déu-Hospital Clinic, Barcelona.

出版信息

Rev Neurol. 1995 May-Jun;23(121):635-8.

PMID:8597985
Abstract

The aim of this study is to analyse different aspects of the psychomotor development, during the first two years of the life, of 56 very low birth weight newborns (less of 1.501 g) that had completed a follow-up program. Of the results we have got, the most important are the following: 4 observations (7%) presented severe sequelae motor disability in a tetraparesis with sensorial defects in 3 of them and behavior disturbance (psychosis) with visual defect in the rest. Three observations (5.3%) presented moderate sequelae: all of them with motor disability (hemi- or tetraparesis) and cognitive deficiency. Me have to point out that in the two groups described above, the pathological signs were detected before the age of 6 months. Nine observations (16%) presented mild sequelae dominating language delayed (7% of whole sample) and transient abnormalities in 7 of them (12.5%). In the subgroup of small for gestational age newborns (21 observations), 28.5% presented mild sequelae, 14% transient abnormalities and no one presented severe or moderate sequelae. Although a long term follow-up is necessary in order to detect learning, cognitive, or behavior disturbances, that can just become evident later, we think that the attention of the deviations of the normality during the two first years of the life, would warn about possible future disturbances.

摘要

本研究的目的是分析56名极低出生体重新生儿(体重不足1501克)在生命的头两年中完成随访计划后的心理运动发育的不同方面。我们得到的结果中,最重要的如下:4例(7%)出现严重后遗症,表现为四肢瘫痪的运动残疾,其中3例伴有感觉缺陷,其余1例伴有行为障碍(精神病)和视觉缺陷。3例(5.3%)出现中度后遗症:均有运动残疾(偏瘫或四肢瘫)和认知缺陷。必须指出的是,在上述两组中,病理体征在6个月龄之前就被检测到。9例(16%)出现轻度后遗症,主要表现为语言发育迟缓(占整个样本的7%),其中7例(12.5%)有短暂异常。在小于胎龄新生儿亚组(21例观察对象)中,28.5%出现轻度后遗症,14%有短暂异常,无1例出现严重或中度后遗症。尽管为了检测可能在后期才会显现的学习、认知或行为障碍,需要进行长期随访,但我们认为在生命的头两年关注正常发育的偏差,将对未来可能出现的障碍发出警示。

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