Krueger N X, Van Vactor D, Wan H I, Gelbart W M, Goodman C S, Saito H
Division of Tumor Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Cell. 1996 Feb 23;84(4):611-22. doi: 10.1016/s0092-8674(00)81036-3.
DLAR is a receptor-like, transmembrane protein-tyrosine phosphatase in Drosophila that is expressed almost exclusively by developing neurons. Analysis of Dlar loss-of-function mutations shows that DLAR plays a key role during motoneuron growth cone guidance. Segmental nerve b (SNb) motor axons normally exit the common motor pathway, enter the ventral target region, and then synapse on specific ventral muscles. In Dlar mutant embryos, SNb axons bypass their normal target region and instead continue to extend along the common pathway. SNd motor axons also make pathfinding errors, while SNa and SNc axons appear normal. Thus, DLAR controls the ability of certain motor axons to navigate specific choices points in the developing Drosophila nervous system.
DLAR是果蝇中一种类似受体的跨膜蛋白酪氨酸磷酸酶，几乎只在发育中的神经元中表达。对Dlar功能丧失突变的分析表明，DLAR在运动神经元生长锥导向过程中起关键作用。节段性神经b（SNb）运动轴突通常离开共同的运动通路，进入腹侧靶区域，然后与特定的腹侧肌肉形成突触。在Dlar突变胚胎中，SNb轴突绕过其正常靶区域，而是继续沿着共同通路延伸。SNd运动轴突也会出现路径寻找错误，而SNa和SNc轴突看起来正常。因此，DLAR控制某些运动轴突在发育中的果蝇神经系统中导航特定选择点的能力。
