Grissom L E, Griffin G C, Mandell G A
Department of Medical Imaging, Alfred I. duPont Institute, 1600 Rockland Road, Wilmington, DE 19803, USA.
Pediatr Radiol. 1996;26(3):200-2. doi: 10.1007/BF01405299.
A case of hypervitaminosis A (HVA) as a complication of therapy for stage-IV neuroblastoma is presented. The patient was randomized to a trial of 13-cis -retinoic acid (a vitamin A-related compound) after completing routine chemotherapy. This acid was given as a means of maturing potential minimal residual disease. A routine follow-up bone scan revealed areas of increased activity, initially along the midshaft of the right ulna and subsequently bilaterally, which were ultimately found to be due to HVA. Hypervitaminosis A has not been previously reported in this setting, and awareness of the condition is important in centers where this treatment is contemplated.
