Serial transplantation in SCID mice of an epidermodysplasia verruciformis-associated squamous cell carcinoma without alteration of its histological and virological features.

An epidermodysplasia verruciformis-associated squamous cell carcinoma was xenografted to a SCID mouse, and the resultant tumor was transplanted through mice for 10 generations. Histological and virological features, with replication of about a thousand copies of the papillomavirus DNA, were the same in both the original carcinoma and the transplanted tumors.